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Actors
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Antonio Banderas .... Gregorio Cortez
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Carla Gugino .... Ingrid Cortez
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Alexa Vega .... Carmen Cortez
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Daryl Sabara .... Juni Cortez
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Alan Cumming .... Fegan Floop
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Tony Shalhoub .... Alexander Minion
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Teri Hatcher .... Ms. Gradenko
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Cheech Marin .... Felix Gumm
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Robert Patrick .... Mr. Lisp
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Danny Trejo .... Machete
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Mike Judge
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Donnagon / Donnamight
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Richard Linklater .... Cool Spy
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Guillermo Navarro .... Pastor
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Johnny Reno
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Agent Johnny
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Shannon Shea
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FoOglie #1 / Flower
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Norman Cabrera
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FoOglie #2 / Tall & Skinny
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Trant Batey
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FoOglie #3 / Too Too
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Andy W. Bossley
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Brat
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Jeffrey J. Dashnaw
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Brat's Dad (as Jeff Dashnaw)
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Kara Slack
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Carmen's Friend
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Ermahn Ospina
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Cab Driver
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Emilio Navarro-Mackissack
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Excited Kid at Playground (as Emilio Navarro Mackissack)
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Evan Sabara
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'Intruder' Spy Kid
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Rachel Duhame
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President's Robot Daughter
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Houston Hooker
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Lisp's Robot Son
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Addisyn Fair
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Baby Carmen
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Louis Black
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Financier
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Charles Ramirez-Berg
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Financier
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Dick Clark
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Financier
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Steve Havens
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Financier
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Roberto Santibáñez
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Financier (as Roberto Santibanez)
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Julio Villareal
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Spy Driver
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Rebecca Rodriguez
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Spy Bridesmaid (as Becca Rodriguez)
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Patricia Vonne
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Spy Bridesmaid
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Angela Lanza
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Newscaster
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George Clooney .... Devlin
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Brinton Bryan
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FoOglie #3 / Too Too / Thumb Thumb / Shape Monster (uncredited)
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Devin Carbaugh
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ThumbThumb (uncredited)
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Jeremy Denzlinger
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Thumb Thumb (uncredited)
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Jace Jeanes
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Monster (uncredited)
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Zoe Keller
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Robot Kid (uncredited)
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Lin Oeding
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Thumb Thumb / Shape Monster (uncredited)
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Troy Robinson
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Floop & Mr. Lisp Bodyguard / Henchman #1 (uncredited)
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Director
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Robert Rodriguez
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Producer
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Elizabeth Avellan
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Cary Granat
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Bill Scott
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Tamara Smith
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Bob Weinstein
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Harvey Weinstein
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Cinematography