I Am Legend

 (2007)
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I Am Legend
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Plot 1
'Years after a plague kills most of humanity and transforms the rest into monsters, the sole survivor in New York City struggles valiantly to find a cure.'
Plot 2
I Am Legend is a 1954 science fiction/horror novel by American writer Richard Matheson. It was influential in the development of the vampire genre as well as the zombie genre, in popularizing the concept of a worldwide apocalypse due to disease, and in exploring the notion of vampirism as a disease. The novel was a success and was adapted to film as The Last Man on Earth in 1964, as The Omega Man in 1971, and as I Am Legend in 2007, along with an unofficial direct to video capitalizing on that film, I Am Omega.

Source: Wikipedia