21 Grams

This is the story of three gentle persons: Paul Rivers (Penn) an ailing mathematician lovelessly married to an English emigré (Gainsbourg), Christina Peck, an upper-middle-class suburban housewife, happily married and mother of two little girls, and Jack Jordan (Del Toro), an ex-convict who has found in his Christian faith the strength to raise a family. They will be brought together by a terrible accident that will change their lives. By the final frame, none of them will be the same as they will learn harsh truths about love, faith, courage, desire and guilt, and how chance can change our worlds irretrievably, forever.

21 Grams is a 2003 film drama directed by Alejandro González Iñárritu and written by Guillermo Arriaga. It stars Sean Penn, Naomi Watts, Caroline Belina, and Benicio del Toro.

Source: Wikipedia