Actor
- Alpha Numeric (2010) .... Tea Baker
- The Private Lives of Pippa Lee (2009) .... Sandra Dulles
- The Informers (2009) .... Cheryl Laine
- Star Trek (2009) .... Amanda Grayson
- Special zu 'Star Trek XI' (2009) .... Herself
- Stay Cool (2009) .... Scarlet Smith
- Scream Awards 2008 (2008) .... Herself - Presenter
- Premio Donostia a Antonio Banderas (2008) .... Blanca Trueba (archive footage)
- The Ten (2008) .... Kelly La Fonda
- Sex and Death 101 (2008) .... Death Nell / Gillian De Raisx (#101)
- The Last Word (2008) ....
- Water Pills (2008) .... Carrie
- Welcome (2007) .... Cynthia
- Premio Donostia a Richard Gere (2007) .... Charlotte Fielding (archive footage)
- Marc Jacobs & Louis Vuitton (2007) .... Herself
- Cómo conseguir un papel en Hollywood (2007) .... Herself (archive footage)
- Camino de Antonio Banderas, El (2006) .... Blanca Trueba (archive footage)
- A Scanner Darkly (2006) .... Donna Hawthorne
- The Darwin Awards (2006) .... Siri Taylor
- 100 Greatest Teen Stars (2006) .... Herself (archive footage)
- The Heart Is Deceitful Above All Things (2005) .... Psychologist (uncredited)
- E! True Hollywood Story Angelina Jolie (2005) .... Herself
- St. Richard of Austin (2004) .... Herself
- Moving Image Salutes Richard Gere (2004) ....
- The Hollywood Greats Anthony Hopkins (2004) .... Herself
- 200 Greatest Pop Culture Icons (2003) .... Herself (archive footage)
- Cher: The Farewell Tour (2003) .... Charlotte Flax (archive footage)
- The Day My God Died (2003) .... Narrator (voice)
- 101 Most Shocking Moments in Entertainment (2003) .... Herself (archive footage)
- S1m0ne (2002) .... Nicola Anders
- Mr. Deeds (2002) .... Babe Bennett
- Reel Comedy: Mr. Deeds (2002) .... Herself
- Zoolander (2001) .... Herself (uncredited)
- The 73rd Annual Academy Awards (2001) .... Herself - Presenter: song 'I've Seen It All'
- F·r·i·e·n·d·s The One with Rachel's Big Kiss (2001) .... Melissa Warburton
- Saturday Night Live Christopher Walken/Weezer (2001) .... Herself (uncredited)
- Lost Souls (2000) .... Maya Larkin
- Autumn in New York (2000) .... Charlotte Fielding
- Girl, Interrupted (2000) .... Susanna Kaysen
- HBO First Look The Making of 'Girl, Interrupted' (2000) .... Herself
- Being John Malkovich (1999) .... Herself (archive footage) (uncredited)
- The Making of 'Girl, Interrupted' (1999) .... Herself
- Celebrity (1998) .... Nola
- Bravo Profiles: The Entertainment Business (1998) .... Herself
- Christopher Reeve: A Celebration of Hope (1998) .... Herself
- Alien: Resurrection (1997) .... Annalee Call
- The Crucible (1996) .... Abigail Williams
- Looking for Richard (1996) .... Lady Anne
- Boys (1996) .... Patty Vare
- Dr. Katz, Professional Therapist Monte Carlo (1996) .... Winona (voice)
- How to Make an American Quilt (1995) .... Finn Dodd
- The 67th Annual Academy Awards (1995) .... Herself - Nominee: Best Actress in a Leading Role
- Little Women (1994) .... Jo March
- The House of the Spirits (1994) .... Blanca Trueba
- Reality Bites (1994) .... Lelaina Pierce
- The Age of Innocence (1993) .... May Welland
- Dracula (1992) .... Mina Murray / Elisabeta
- Innocence and Experience: The Making of 'The Age of Innocence' (1992) .... Herself
- Blood Lines: Dracula - The Man. The Myth. The Movies. (1992) .... Herself
- Night on Earth (1991) .... Corky
- Mermaids (1990) .... Charlotte Flax
- Edward Scissorhands (1990) .... Kim
- Welcome Home, Roxy Carmichael (1990) .... Dinky Bossetti
- In the Director's Chair: The Man Who Invented Edward Scissorhands (1990) .... Herself
- Great Balls of Fire! (1989) .... Myra Gale Brown
- Heathers (1989) .... Veronica
- 1969 (1988) .... Beth
- Beetle Juice (1988) .... Lydia Deetz
- Square Dance (1987) .... Gemma
- Lucas (1986) .... Rina
- The Day My God Died (2003) .... producer
- Girl, Interrupted (2000) .... executive producer
- Murderball (2005) .... special thanks
- Modigliani (2004) .... thanks
- Being John Malkovich (1999) .... acknowledgment
- The Making of 'Girl, Interrupted' (1999) .... thanks