Actor
- Percy Jackson & the Olympians: The Lightning Thief (2010) .... Medusa
- Motherhood (2009) .... Eliza Welsh
- A Muppets Christmas: Letters to Santa (2008) .... Joy
- The Life Before Her Eyes (2008) .... Diana McFee
- The Accidental Husband (2008) .... Dr. Emma Lloyd
- My Zinc Bed (2008) ....
- Do Not Alter (2008) ....
- The City If She Can Make It Here... (2008) .... Herself
- The 17th Annual Gotham Awards (2007) .... Herself
- The Naked Brothers Band: The Movie (2007) .... Herself
- Marc Jacobs & Louis Vuitton (2007) .... Herself
- Mission Zero (2007) .... Herself
- My Super Ex-Girlfriend (2006) .... Jenny Johnson / G-Girl
- 1 Leicester Square (2006) .... Herself (1 episode, 2006)
- Boffo! Tinseltown's Bombs and Blockbusters (2006) .... Mia Wallace (archive footage) (uncredited)
- The Producers (2005) .... Ulla
- Prime (2005) .... Rafi Gardet
- Be Cool (2005) .... Edie Athens
- Tsunami Aid: A Concert of Hope (2005) .... Herself
- Reel Comedy: Be Cool (2005) .... Herself
- 10 Most Excellent Things: The Producers (2005) .... Herself
- Cinema mil Episode #1.2 (2005) .... Herself (archive footage)
- 'Pulp Fiction' on a Dime: A 10th Anniversary Retrospect (2004) .... Herself (also archive footage)
- Kill Bill: Vol. 2 (2004) .... Beatrix Kiddo - The Bride, 'Black Mamba'
- From Hong Kong to Hollywood: The Making of John Woo (2004) .... Herself
- Remembering the Future: Paycheck & the Worlds of Philip K. Dick (2004) .... Herself
- The Making of 'Kill Bill: Volume 2' (2004) .... Herself
- The Ultimate Hollywood Blonde (2004) .... Herself (archive footage)
- Paycheck (2003) .... Rachel
- Hysterical Blindness (2003) .... Debby Miller
- Kill Bill: Vol. 1 (2003) .... The Bride
- The Making of 'Kill Bill' (2003) .... Herself
- Cartaz Cultural (2003) .... Herself
- Tape (2002) .... Amy Randall
- All the Love You Cannes! (2002) .... Herself
- Power of Peace (2001) .... Herself - Host
- Chelsea Walls (2001) .... Grace
- The Golden Bowl (2000) .... Charlotte Stant
- Vatel (2000) .... Anne de Montausier
- Sweet and Lowdown (2000) .... Blanche
- Without Lying Down: Frances Marion and the Power of Women in Hollywood (2000) .... Narrator (voice)
- The Avengers (1998) .... Emma Peel
- Misérables, Les (1998) .... Fantine
- The Clive James Show (1998) .... Herself (1 episode, 1998)
- Gattaca (1997) .... Irene Cassini
- Batman & Robin (1997) .... Poison Ivy / Dr. Pamela Isley
- You're Still Not Fooling Anybody (1997) .... Herself (archive footage) (uncredited)
- The Truth About Cats & Dogs (1996) .... Noelle
- Beautiful Girls (1996) .... Andera
- Duke of Groove (1996) .... Maya
- A Month by the Lake (1995) .... Miss Beaumont
- The 67th Annual Academy Awards (1995) .... Herself - Nominee: Best Actress in a Supporting Role & Presenter: Best Makeup
- Pulp Fiction (1994) .... Mia Wallace
- Even Cowgirls Get the Blues (1994) .... Sissy Hankshaw
- Mad Dog and Glory (1993) .... Glory
- Jennifer Eight (1992) .... Helena Robertson
- Final Analysis (1992) .... Diana Baylor
- Robin Hood (1991) .... Maid Marian
- Henry & June (1990) .... June Miller
- Where the Heart Is (1990) .... Daphne McBain
- Dangerous Liaisons (1988) .... Cécile de Volanges
- Kiss Daddy Goodnight (1988) .... Laura
- Johnny Be Good (1988) .... Georgia Elkans
- The Adventures of Baron Munchausen (1988) .... Venus / Rose
- Kaze no tani no Naushika (Warriors of the Wind) (1984) .... Kushana (voice: English version)
- The Accidental Husband (2008) .... producer
- Hysterical Blindness (2003) .... executive producer
- 'Pulp Fiction' on a Dime: A 10th Anniversary Retrospect (2004) .... special thanks
- Hamlet (2000) .... special thanks
- Julian Po (1997) .... acknowledged contributor
- Kill Bill: Vol. 2 (2004) .... (character The Bride) (as U)
- Kill Bill: Vol. 1 (2003) .... (character The Bride) (as U)