Actor
- Chéri (2009) .... Lea de Lonval
- Personal Effects (2009) .... Linda
- Chasing Montana (2008) .... (in talks)
- Forbes 20 Under 25: Young, Rich and Famous (2007) .... Herself (archive footage) (uncredited)
- The 59th Primetime Emmy Awards (2007) .... Herself
- Stardust (2007) .... Lamia
- Hairspray (2007) .... Velma Von Tussle
- I Could Never Be Your Woman (2007) .... Rosie
- 20 to 1 Sexiest Movie Moments (2007) .... Susie Diamond (archive footage) (uncredited)
- The Ultimate Hollywood Blonde (2004) .... Herself (archive footage)
- Sinbad: Legend of the Seven Seas (2003) .... Eris (voice)
- Cher: The Farewell Tour (2003) .... Sukie Ridgemont (archive footage)
- HBO First Look The Making of 'Sinbad: The Legend of the Seven Seas' (2003) .... Herself
- White Oleander (2002) .... Ingrid Magnussen
- I Am Sam (2002) .... Rita Harrison Williams
- What Lies Beneath: Constructing the Perfect Thriller (2001) .... Herself
- What Lies Beneath (2000) .... Claire Spencer
- Twentieth Century Fox: The Blockbuster Years (2000) .... Susie Diamond / Melanie Parker / Titania (archive footage)
- Biography Robert Redford: Hollywood Outlaw (2000) .... Herself (archive footage)
- The Story of Us (1999) .... Katie Jordan
- Telling the Story of Us (1999) .... Herself
- A Midsummer Night's Dream (1999) .... Titania
- The Deep End of the Ocean (1999) .... Beth Cappadora
- Exclusif (1999) .... Herself (1 episode, 2002)
- The Prince of Egypt (1998) .... Tzipporah (voice)
- Bravo Profiles: The Entertainment Business (1998) .... Herself
- The Uttmost (1998) .... Herself
- A Thousand Acres (1997) .... Rose Cook Lewis
- One Fine Day (1996) .... Melanie Parker
- To Gillian on Her 37th Birthday (1996) .... Gillian Lewis
- Up Close & Personal (1996) .... Sally / Tally Atwater
- Dangerous Minds (1995) .... Louanne Johnson
- Wolf (1994) .... Laura Alden
- Discovering Women (1994) .... Narrator (voice)
- The Age of Innocence (1993) .... Ellen Olenska
- Hollywood's Leading Ladies with David Sheehan (1993) .... Herself
- The Simpsons The Last Temptation of Homer (1993) .... Mindy Simmons (voice)
- Love Field (1992) .... Lurene Hallett
- Batman Returns (1992) .... Catwoman / Selina Kyle
- HBO First Look (1992) .... Herself (5 episodes, 1998-2007)
- The Bat, the Cat, and the Penguin (1992) .... Herself
- Innocence and Experience: The Making of 'The Age of Innocence' (1992) .... Herself
- Frankie and Johnny (1991) .... Frankie
- Voices that Care (1991) .... Herself - Choir Member
- The Russia House (1990) .... Katya Orlova
- The 62nd Annual Academy Awards (1990) .... Herself - Nominee: Best Actress in a Leading Role & Presenter: International Segment
- The Fabulous Baker Boys (1989) .... Susie Diamond
- Dangerous Liaisons (1988) .... Madame Marie de Tourvel
- Tequila Sunrise (1988) .... Jo Ann Vallenari
- Married to the Mob (1988) .... Angela de Marco
- Amazon Women on the Moon (1987) .... Brenda Landers (segment "Hospital")
- The Witches of Eastwick (1987) .... Sukie Ridgemont
- Tales from the Hollywood Hills: Natica Jackson (1987) .... Natica Jackson
- Sweet Liberty (1986) .... Faith Healy
- Ladyhawke (1985) .... Isabeau d'Anjou
- Into the Night (1985) .... Diana
- ABC Afterschool Specials One Too Many (1985) .... Annie
- Scarface (1983) .... Elvira Hancock
- Grease 2 (1982) .... Stephanie Zinone
- The Children Nobody Wanted (1981) .... Jennifer Williams
- Splendor in the Grass (1981) .... Ginny Stamper
- Callie & Son (1981) .... Sue Lynn Bordeaux (as Michele Pfeiffer)
- Charlie Chan and the Curse of the Dragon Queen (1981) .... Cordelia Farenington
- The Hollywood Knights (1980) .... Suzie Q
- B.A.D. Cats (1980) .... Samantha 'Sunshine' Jensen (10 episodes, 1980)
- Falling in Love Again (1980) .... Sue Wellington
- The Solitary Man (1979) .... Tricia
- A Thousand Acres (1997) .... producer (uncredited)
- One Fine Day (1996) .... executive producer
- Being John Malkovich (1999) .... acknowledgment