Actor
- Sin City 2 (2010) .... Manute
- Sin City 3 (2010) .... Manute
- The Slammin' Salmon (2009) .... Cleon 'Slammin' Salmon
- Street Fighter: The Legend of Chun-Li (2009) .... Balrog / Bison (Japan)
- For Love of Liberty: The Story of America's Black Patriots (2009) .... (voice)
- Delgo (2008) .... Elder Marley (voice)
- Kung Fu Panda (2008) .... Commander Vachir (voice)
- Slipstream (2008) .... Mort / Phil Henderson / Patrolman
- Welcome Home, Roscoe Jenkins (2008) .... Otis
- The Girls Next Door She Got Game (2008) .... Himself (as Michael Clark Duncan)
- The Suite Life of Zack and Cody Benchwarmers (2008) .... Coach Little
- Two and a Half Men The Mooch at the Boo (2008) .... Jerome 'Mad Dog' Burnett
- They Call Me Sirr (2007) .... Coach Griffin
- The Last Mimzy (2007) .... Nathanial Broadman
- An Evening of Stars: Tribute to Aretha Franklin (2007) .... Himself
- One Way (2007) .... The General
- American Crude (2007) .... Spinks
- School for Scoundrels (2006) .... Lesher
- Pursued (2006) .... Franklin
- Talladega Nights: The Ballad of Ricky Bobby (2006) .... Lucius Washington
- Reel Comedy: Talladega Nights - The Ballad of Ricky Bobby (2006) .... Himself
- Boffo! Tinseltown's Bombs and Blockbusters (2006) .... John Coffey (archive footage) (uncredited)
- Family Guy Stu & Stewie's Excellent Adventure (2006) .... (voice)
- Family Guy You May Now Kiss the... Uh... Guy Who Receives (2006) .... Boy on Mushrooms (voice)
- The Island (2005) .... Starkweather
- Sin City: The Premiere (2005) .... Himself
- Dinotopia: Quest for the Ruby Sunstone (2005) .... Stinktooth (voice)
- Sin City (2005) .... Manute
- Starz on the Set: Sin City (2005) .... Himself
- D.E.B.S. (2005) .... Mr. Phipps
- Racing Stripes (2005) .... Clydesdale (voice)
- George Lopez George to the Third Power (2005) .... Dr. Holland
- Biography Bruce Willis (2005) .... Himself
- Teen Titans Cyborg the Barbarian (2005) .... Krall / Hayden (voice)
- Crash Nebula (2004) .... Rockwell (voice)
- UFC 47: It's On! (2004) .... Himself
- George and the Dragon (2004) .... Tarik
- Kim Possible: A Sitch in Time (2003) .... Future Wade (voice)
- Brother Bear (2003) .... Tug (voice)
- UFC 44: Undisputed (2003) .... Himself
- Daredevil (2003) .... Wilson Fisk / The Kingpin
- Daredevil: From the Comic to the Big Screen (2003) .... Himself
- The Proud Family Smackmania 6: Mongo vs. Mama's Boy (2003) .... Mongo (voice)
- Secrets of Superstar Fitness (2002) .... Himself
- The Scorpion King (2002) .... Balthazar
- King of the Hill The Son Also Roses (2002) .... Coach Webb (voice)
- Planet of the Apes (2001) .... Attar
- Cats & Dogs (2001) .... Sam (voice)
- See Spot Run (2001) .... Murdoch
- The Making of 'Planet of the Apes' (2001) .... Himself / Host
- E! True Hollywood Story Joan Rivers (2001) .... Himself
- WrestleMania 2000 (2000) .... Himself
- The Whole Nine Yards (2000) .... Franklin 'Frankie Figs' Figueroa
- The Green Mile (1999) .... John Coffey
- The Miracle of 'The Green Mile' (1999) .... Himself
- The Underground Comedy Movie (1999) .... Gay Virgin
- Breakfast of Champions (1999) .... Eli (as Michael Duncan)
- Sister, Sister Before There Was Hip Hop... (1999) .... Big Earl
- A Night at the Roxbury (1998) .... Roxbury Bouncer (as Michael 'Big Mike' Duncan)
- Armageddon (1998) .... Jayotis 'Bear' Kurleenbear
- Bulworth (1998) .... Bouncer (as Michael 'Big Mike' Duncan)
- The Players Club (1998) .... Bodyguard
- Caught Up (1998) .... BB
- Built to Last (1997) .... (1 episode, 1997)
- Back in Business (1997) .... Huge Guard
- Skwids (1996) .... Body Builder
- Friday (1995) .... Craps Player (uncredited)
- The Fresh Prince of Bel-Air Bourgie Sings the Blues (1995) .... Tiny
- Married with Children Flight of the Bumblebee (1995) .... Bouncer (as Michael Clarke Duncan)