Actor
- It's Complicated (2009) .... Jane
- Fantastic Mr. Fox (2009) .... Mrs. Fox (voice)
- Julie & Julia (2009) .... Julia Child
- Star Movies: Live from the Red Carpet (2009) .... Herself
- 81st Annual Academy Awards (2009) .... Herself - Nominee: Best Actress in a Leading Role
- 15th Annual Screen Actors Guild Awards (2009) .... Herself - Winner Female Actor in a Leading Role
- The 66th Annual Golden Globe Awards (2009) .... Herself
- I Knew It Was You: Rediscovering John Cazale (2009) .... Herself
- Doubt (2008) .... Sister Aloysius Beauvier
- The Magic 7 (2008) .... Herself
- Roman Polanski: Wanted and Desired (2008) .... Herself (archive footage)
- Harvard Beats Yale 29-29 (2008) .... Herself (archive footage)
- Premio Donostia a Meryl Streep (2008) .... Herself - Honoree
- Ceremonia de inauguración - 56º festival internacional de cine de San Sebastián (2008) .... (archive footage)
- Stand Up to Cancer (2008) .... Herself
- Mamma Mia! (2008) .... Donna Sheridan
- Oscar, que empiece el espectáculo (2008) .... Herself (archive footage) (uncredited)
- Irak-Afganistán, la guerra llega al cine (2008) .... Herself (archive footage)
- Dirty Tricks (2008) .... Martha Mitchell
- Imaginary Witness: Hollywood and the Holocaust (2007) .... (archive footage)
- Lions for Lambs (2007) .... Janine Roth
- Rendition (2007) .... Corrine Whitman
- Evening (2007) .... Lila Ross
- Penélope, camino a los Oscar (2007) .... Herself (archive footage) (uncredited)
- Dark Matter (2007) .... Joanna Silver
- The O'Reilly Factor Episode dated 13 December 2007 (2007) .... Herself (archive footage)
- The Ant Bully (2006) .... Queen (voice)
- The Devil Wears Prada (2006) .... Miranda Priestly
- A Prairie Home Companion (2006) .... Yolanda Johnson
- Al Pacino: An American Cinematheque Tribute (2006) .... Herself
- Boffo! Tinseltown's Bombs and Blockbusters (2006) .... Karen Christence Dinesen Blixen (archive footage) (uncredited)
- Hurricane on the Bayou (2006) .... Narrator
- The Music of Regret (2006) .... The Woman
- Wrestling with Angels: Playwright Tony Kushner (2006) .... Herself
- At the Movies Episode dated 27 September 2006 (2006) .... Herself
- Prime (2005) .... Lisa Metzger
- Oficio de actor, El (2005) .... Francesca Johnson (archive footage)
- Stolen Childhoods (2005) .... Herself - narrator (voice)
- Biography Bruce Willis (2005) .... Herself
- Lemony Snicket's A Series of Unfortunate Events (2004) .... Aunt Josephine
- Monet's Palate: A Gastronomic View from the Gardens of Giverny (2004) .... Narrator
- Jonathan Demme and the Making of 'The Manchurian Candidate' (2004) .... Herself
- The Manchurian Candidate (2004) .... Eleanor Shaw
- Stuck on You (2003) .... Herself (uncredited)
- Angels in America (2003) .... Ethel Rosenberg / ... (6 episodes, 2003)
- What Not to Wear on the Red Carpet (2003) .... Herself (Interviewed at The BAFTA Film Awards: 23rd February 2003)
- Cartaz Cultural (2003) .... Herself (2008)
- The Hours (2003) .... Clarissa Vaughan
- Adaptation. (2003) .... Susan Orlean
- There's Only One Paul McCartney (2002) .... Herself
- New York at the Movies (2002) .... Narrator
- A Quiet Revolution (2002) .... Narrator
- Movie Show Plus (2002) .... Himself
- Nobel Peace Prize Concert (2001) .... Herself - Host
- Vermeer: Master of Light (2001) .... Narrator
- School (2001) .... Narrator (voice)
- Artificial Intelligence: AI (2001) .... Blue Mecha (voice)
- "Intimate Portrait" Diane Keaton (2001) .... Herself
- The Papp Project (2001) .... Herself
- American Masters Clint Eastwood: Out of the Shadows (2000) .... Herself - Actor
- American Masters Clint Eastwood: Out of the Shadows (2000) .... Herself - Actor
- Music of the Heart (1999) .... Roberta Guaspari
- From Star Wars to Star Wars: The Story of Industrial Light & Magic (1999) .... Herself
- The Directors (1999) .... Herself (4 episodes, 1999-2005)
- King of the Hill A Beer Can Named Desire (1999) .... Aunt Esme Dauterive (voice)
- Dancing at Lughnasa (1998) .... Kate 'Kit' Mundy
- One True Thing (1998) .... Kate Gulden
- Christopher Reeve: A Celebration of Hope (1998) .... Herself
- Defending Our Daughters: The Rights of Women in the World (1998) .... Herself - Host
- ...First Do No Harm (1997) .... Lori Reimuller
- Marvin's Room (1997) .... Lee
- Assignment: Rescue (1997) .... Narrator (voice)
- Before and After (1996) .... Dr. Carolyn Ryan
- 50 Years of Funny Females (1995) .... Herself (archive footage)
- The Bridges of Madison County (1995) .... Francesca Johnson
- The Living Sea (1995) .... Narrator (voice)
- The River Wild (1994) .... Gail Hartman
- A Century of Women (1994) .... (voice)
- The House of the Spirits (1994) .... Clara del Valle Trueba
- A Century of Cinema (1994) .... Herself
- Death Becomes Her (1992) .... Madeline Ashton
- Defending Your Life (1991) .... Julia
- Voices that Care (1991) .... Herself - Choir Member
- Age 7 in America (1991) .... Narrator (voice)
- Postcards from the Edge (1990) .... Suzanne Vale
- Race to Save the Planet (1990) .... Hostess
- An Evening with... (1990) .... Herself
- The Earth Day Special (1990) .... Herself
- Cilla's Goodbye to the '80s (1989) ....
- She-Devil (1989) .... Mary Fisher
- Evil Angels (1988) .... Lindy Chamberlain
- The 60th Annual Academy Awards (1988) .... Herself - Nominee: Best Actress in a Leading Role
- Ironweed (1987) .... Helen Archer
- Heartburn (1986) .... Rachel Samstat
- Out of Africa (1985) .... Karen Blixen
- Plenty (1985) .... Susan Traherne
- Falling in Love (1984) .... Molly Gilmore
- In Our Hands (1984) .... Herself
- Silkwood (1983) .... Karen Silkwood
- Sophie's Choice (1982) .... Sophie Zawistowski
- Still of the Night (1982) .... Brooke Reynolds
- Alice at the Palace (1982) .... Alice
- The French Lieutenant's Woman (1981) .... Sarah / Anna
- Sixty Years of Seduction (1981) .... (archive footage)
- Kiss Me, Petruchio (1981) .... Katherine
- Omnibus (1980) .... Herself (1 episode, 1980)
- Kramer vs. Kramer (1979) .... Joanna Kramer
- The Seduction of Joe Tynan (1979) .... Karen Traynor
- Uncommon Women... and Others (1979) .... Leilah
- Manhattan (1979) .... Jill Davis
- The Deer Hunter (1979) .... Linda
- Holocaust (1978) .... Inga Helms Weiss
- Julia (1978) .... Anne Marie
- The Deadliest Season (1977) .... Sharon Miller
- Secret Service (1977) .... Edith Varney
- Everybody Rides the Carousel (1975) .... Stage 6 (voice)
- The Directors The Films of Wes Craven (1960) .... Herself
- ...First Do No Harm (1997) .... executive producer
- Stuck on You (2003) .... special thanks
- American Masters Clint Eastwood: Out of the Shadows (2000) .... thanks
- American Masters Clint Eastwood: Out of the Shadows (2000) .... thanks


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