Actor
- Nobel Son (2008) .... Sarah Michaelson
- Four Christmases (2008) .... Marilyn
- Step Brothers (2008) .... Nancy Huff
- Honeydripper (2008) .... Amanda Winship
- In the Electric Mist (2008) .... Bootsie Robicheaux
- The Brave One (2007) .... Carol
- The Dead Girl (2007) .... Beverley, Leah's Mother
- Inland Empire (2007) .... Visitor #2
- Elvis and Anabelle (2007) .... Geneva
- Numb (2007) .... Dr. Cheryl Blaine
- Marilyn Hotchkiss Ballroom Dancing & Charm School (2006) .... Marienne Hotchkiss
- O Lucky Malcom! (2006) .... Herself
- Casa de los babys (2004) .... Gayle
- Elf (2003) .... Emily
- Beyond Borders: John Sayles in Mexico (2003) .... Herself
- Hope Springs (2003) .... Joanie Fisher
- Sunshine State (2002) .... Francine Pinkney
- I Am Sam (2002) .... Dr. Blake
- Wish You Were Dead (2002) .... Sally Rider
- Life as a House (2001) .... Colleen Beck
- The Trumpet of the Swan (2001) .... Mother (voice)
- Nobody's Baby (2001) .... Estelle
- The Grass Harp (1996) .... Sister Ida
- Nixon (1995) .... Hannah Nixon
- Powder (1995) .... Jessie Caldwell
- My Family (1995) .... Gloria
- It Runs in the Family (1994) .... Mrs. Parker (Mother)
- Clifford (1994) .... Sarah Davis
- Pontiac Moon (1994) .... Katherine Bellamy
- What's Eating Gilbert Grape (1993) .... Betty Carver
- Philadelphia (1993) .... Belinda Conine
- Earth and the American Dream (1992) .... Reader (voice)
- The Butcher's Wife (1991) .... Stella Keefover
- Back to the Future Part III (1990) .... Clara Clayton
- Miss Firecracker (1990) .... Elain Rutledge
- The Long Walk Home (1990) .... Narrator (voice)
- Parenthood (1989) .... Karen Buckman
- End of the Line (1987) .... Rose Pickett
- Dead of Winter (1987) .... Julie Rose / Katie McGovern / Evelyn
- The Whales of August (1987) .... Young Sarah
- One Magic Christmas (1985) .... Ginny Hanks Grainger
- Cross Creek (1985) .... Marjorie Kinnan Rawlings
- Sanford Meisner: The American Theatre's Best Kept Secret (1985) .... Herself
- Romantic Comedy (1984) .... Phoebe Craddock
- A Midsummer Night's Sex Comedy (1982) .... Adrian
- Ragtime (1982) .... Mother
- Melvin and Howard (1980) .... Lynda Dummar
- Time After Time (1979) .... Amy Robbins
- Goin' South (1978) .... Julia Tate / Moon
- Bye Bye Benjamin (2006) .... executive producer
- End of the Line (1987) .... executive producer
- O Lucky Malcom! (2006) .... acknowledgment: photos
- Alex in Wonder (2001) .... special thanks