Actor
- The 14th Annual Critics' Choice Awards (2009) .... Herself - Presenter
- The 66th Annual Golden Globe Awards (2009) .... Herself - Winner
- TV Guide Live at the Emmy Awards (2008) .... Herself
- The 60th Primetime Emmy Awards (2008) .... Herself - Nominee: Supporting Actress in a Miniseries or a Movie
- Recount (2008) .... Katherine Harris
- Oscar, que empiece el espectáculo (2008) .... Herself (archive footage) (uncredited)
- Jurassic Park IV (2008) .... Dr. Ellie Sattler (rumored)
- Tenderness (2008) ....
- The Monday Before Thanksgiving (2008) .... Theresa
- Year of the Dog (2007) .... Bret
- The Prize Winner of Defiance, Ohio (2007) .... Dortha Schaefer
- Cannes, 60 ans d'histoires (2007) .... Herself (archive footage)
- Inland Empire (2007) .... Nikki Grace / Susan Blue
- Ecoist (2007) .... Herself
- Lonely Hearts (2006) .... Rene Fodie
- All We Are Saying (2006) .... Herself
- Premio Donostia a Willem Dafoe (2005) .... Lula Pace (archive footage) (uncredited)
- Happy Endings (2005) .... Pam
- E! True Hollywood Story Angelina Jolie (2005) .... Herself (archive footage)
- We Don't Live Here Anymore (2004) .... Terry Linden
- Making of 'Ladies and Gentlemen, the Fabulous Stains' (2004) .... Herself
- King of the Hill Patch Boomhauer (2003) .... Katherine (voice)
- Searching for Debra Winger (2002) .... Herself
- Damaged Care (2002) .... Linda Peeno
- Focus (2002) .... Gertrude 'Gert' Hart
- I Am Sam (2002) .... Randy Carpenter
- The West Wing The U.S. Poet Laureate (2002) .... U.S. Poet Laureate Tabatha Fortis
- King of the Hill Joust Like a Woman (2002) .... Serving Wench (voice)
- Novocaine (2001) .... Jean Noble
- Within These Walls (2001) .... Sister Pauline Quinn
- Jurassic Park III (2001) .... Dr. Ellie Sattler
- Daddy and Them (2001) .... Ruby Montgomery
- Dr T and the Women (2000) .... Peggy
- October Sky (1999) .... Miss Frieda Riley
- AFI's 100 Years... 100 Stars (1999) .... Herself
- The Directors (1999) .... Herself (3 episodes, 2003)
- Hallmark Hall of Fame A Season for Miracles (1999) .... Berry Thompson
- The Baby Dance (1998) .... Wanda LeFauve
- Warner Bros. 75th Anniversary: No Guts, No Glory (1998) .... Herself
- Bastard Out of Carolina (1996) .... Narrator (voice)
- Citizen Ruth (1996) .... Ruth Stoops
- The Siege at Ruby Ridge (1996) .... Vicki Weaver
- Down Came a Blackbird (1995) .... Helen McNulty
- Frasier Sleeping with the Enemy (1995) .... June (voice)
- A Century of Women (1994) .... Family Member (voice)
- A Perfect World (1993) .... Sally Gerber
- Jurassic Park (1993) .... Dr. Ellie Sattler
- The Last Party (1993) .... Herself (uncredited)
- Afterburn (1992) .... Janet Harduvel
- The 18th Annual People's Choice Awards (1992) .... Herself
- Rambling Rose (1991) .... Rose
- Jonathan Ross Presents for One Week Only: David Lynch (1990) .... Herself
- Wild at Heart (1990) .... Lula Fortune
- Industrial Symphony No. 1: The Dream of the Brokenhearted (1990) .... Heartbroken Woman
- Fat Man and Little Boy (1989) .... Kathleen Robinson
- Haunted Summer (1988) .... Claire Clairmont
- Predator: The Concert (1987) ....
- Blue Velvet (1986) .... Sandy Williams
- Smooth Talk (1986) .... Connie
- Mask (1985) .... Diana Adams
- The Three Wishes of Billy Grier (1984) .... Crissy
- Teachers (1984) .... Diane
- Happy Endings (1983) .... Audrey Constantine
- Ladies and Gentlemen, the Fabulous Stains (1981) .... Jessica McNeil
- Foxes (1980) .... Debbie
- Alice Doesn't Live Here Anymore (1975) .... Girl Eating Ice Cream Cone (uncredited)
- White Lightning (1973) .... Sharon Anne, Maggie's Daughter (uncredited)
- The Gift (1994) ....
- Inland Empire (2007) .... co-producer
- Damaged Care (2002) .... co-producer
- Down Came a Blackbird (1995) .... executive producer
- The Last Real Cowboys (2000) .... special thanks
- Warner Bros. 75th Anniversary: No Guts, No Glory (1998) .... special thanks