Actor
- The Private Lives of Pippa Lee (2009) ....
- Morgan's Summit (2009) .... Gracie Holls
- Shelter (2009) ....
- Blindness (2008) .... Doctor's Wife
- Eagle Eye (2008) .... A.R.I. (voice) (uncredited) (unconfirmed)
- Hateship, Friendship, Courtship (2008) .... (in talks)
- Boone's Lick (2008) .... Mary Margaret (in negotiations)
- I'm Not There. (2007) .... Alice Fabian
- Savage Grace (2007) .... Barbara Baekeland
- The Prize Winner of Defiance, Ohio (2007) .... Evelyn Ryan
- Next (2007) .... Callie Ferris
- Children of Men (2007) .... Julian
- Trust the Man (2006) .... Rebecca
- The Forgotten (2004) .... Telly Paretta
- Laws of Attraction (2004) .... Audrey Woods
- Marie and Bruce (2004) .... Marie
- Signs and Voices (2004) .... Herself
- The Hours (2003) .... Laura Brown
- Far from Heaven (2002) .... Cathy Whitaker
- The Shipping News (2002) .... Wavey Prowse
- Evolution (2001) .... Dr. Allison Reed, CDC
- Hannibal (2001) .... Clarice Starling
- World Traveler (2001) .... Dulcie
- The Ladies Man (2000) .... Audrey
- A Map of the World (2000) .... Theresa Collins
- Magnolia (2000) .... Linda Partridge
- Not I (2000) .... Auditor / Mouth
- Welcome to Hollywood (2000) .... Herself
- The End of the Affair (1999) .... Sarah Miles
- An Ideal Husband (1999) .... Mrs. Laura Cheveley
- Cookie's Fortune (1999) .... Cora Duvall
- Psycho (1998) .... Lila Crane
- Chicago Cab (1998) .... Distraught Woman
- The Big Lebowski (1998) .... Maude Lebowski
- Junket Whore (1998) .... Herself
- Boogie Nights (1997) .... Amber Waves - Maggie
- The Myth of Fingerprints (1997) .... Mia
- The Lost World: Jurassic Park (1997) .... Dr. Sarah Harding
- Surviving Picasso (1996) .... Dora Maar
- Assassins (1995) .... Electra
- Nine Months (1995) .... Rebecca Taylor
- Safe (1995) .... Carol White
- Roommates (1995) .... Beth Holzcek
- Vanya on 42nd Street (1994) .... Yelena
- Short Cuts (1993) .... Marian Wyman
- The Fugitive (1993) .... Dr. Anne Eastman
- Benny & Joon (1993) .... Ruthie
- Body of Evidence (1993) .... Sharon Dulaney
- Luck, Trust & Ketchup: Robert Altman in Carver Country (1993) .... Herself
- The Gun in Betty Lou's Handbag (1992) .... Elinor
- The Hand That Rocks the Cradle (1992) .... Marlene Craven
- Tales from the Darkside: The Movie (1990) .... Susan (segment "Lot 249")
- Hateship, Friendship, Courtship (2008) .... executive producer
- Marie and Bruce (2004) .... executive producer
- Shortbus (2006) .... thanks